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Propulsid - Heartburn Medication Linked to Heart Rhythm Abnormalities and Death
September 2000, Ashcraft & Gerel LLP
Propulsid, a popular medication for severe gastoesophageal reflux disease (GERD) will be pulled from the market as of July 14, 2000 after being linked to 341 reports of heart rhythm abnormalities. At least 80 deaths have been linked to Propulsid, also known as cisapride. This action by the manufacturer follows a January 24, 2000 warning by the Food and Drug Administration in which users were advised to be tested to determine whether heart damage had been sustained.
Most of the adverse events occurred in those patients who had pre-existing medical conditions or were taking other medications. The drug is also contraindicated in those patients with congestive heart failure, a history of heart disease, obstructive pulmonary disease, and advanced cancer.
Because of the risks associated with Propulsid and the many factors that need to be considered in prescribing it, the FDA has advised doctors to use the drug in patients who have not responded to other drug therapies or lifestyle modifications. Patients who are now using Propulsid are advised to consult with their physicians.
Robert Grossman & Associates, LLP
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